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The standard B12 injection protocol typically follows a structured schedule: Initial phase: 100 mcg daily for one week Secondary phase: Every other day for seven doses Maintenance phase: Monthly injections of 100-200 mcg [11] Patients may receive their injections in the thigh, stomach, or upper arm, rotating injection sites weekly [12]

Mol Genet Metab 100:2936 Froese DS, Zhang J, Healy S, Gravel RA (2009) Mechanism of vitamin B12-responsiveness in cblC methylmalonic aciduria with homocystinuria

2019;32: e12625

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Schapira AH, Gegg M (2011) Mitochondrial contribution to Parkinsons disease pathogenesis

If an anaphylactoid reaction (rash, hypotension, wheezing, dyspnea, or any dermatologic manifestations other than flushing and erythema) occurs during IV acetylcysteine therapy, the drug should be temporarily interrupted in order to administer antihistamines and, in severe reactions, epinephrine