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Wang et al (78) treated A549, H1975 and HCC827 cells with 0.2 mM metformin and observed that not only did they inhibit cell proliferation, but they also induced cell cycle arrest in the S phase and increased apoptosis

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High-dose metformin plus temozolomide shows increased anti-tumor effects in glioblastoma in vitro and in vivo compared with monotherapy

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Dietary modifications should focus on: Reducing refined carbohydrates and added sugars, particularly fructose Limiting saturated fats whilst incorporating omega-3 fatty acids Increasing consumption of vegetables, whole grains, and lean proteins Following a Mediterranean-style diet, which evidence suggests benefits liver health Avoiding excessive caloric intake and processed foods Adhering to UK Chief Medical Officers' low-risk drinking guidelines (14 units per week or less, spread over 3 or more days)