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2012;19:S539548

Xia L, Tan S, Zhou Y, Lin J, Wang H, Oyang L, et al

Oxaliplatin-induced neurotoxicity: acute hyperexcitability and chronic neuropathy

To provide further support for the above experimental observations, the isothermal doseresponse CETSA (ITDR CETSA ) was also performed

Recent studies have shown that SIRT1 exerts a neuroprotective effect in MPP+-treated dopaminergic neurons, primarily through deacetylation of PKM2, which improves brain lactate homeostasis and upregulates PGC-1 expression, promoting mitochondrial biogenesis in MPP+-treated cells 8,41