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7.2 Personalized antioxidant strategies: One size does not fit all As the understanding of oxidative stress deepens, it is clear that uniform supplementation strategies may be insufficient

however, the combination might produce delayed healing and less-than-ideal outcomes

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For prevention of contrast-induced acute kidney injury, a meta-analysis found misleading beneficial associations that were lost when analysis was restricted to larger studies (52) , and mechanistic studies showed that oral NAC is poorly absorbed with no renoprotective effects (53)

Support for a role of Mrp1 and Mrp2 in GSH export is provided by studies in knockout mouse models

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