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In animal models, mice were exposed for 60 weeks to the e-cigarette with a concentration of nicotine from 0 to 24 mg/mL showed endothelial dysfunction and an increase in endothelial ROS, in addition to a thickening of the vessel wall were dependent on nicotine concentration (186)

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Center for Tobacco Products, Food and Drug Administration, U.S

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This means that they are tested to prove that they contain no more than 0.3% delta 9 THC