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Animals A total of 37 male Wistar rats (810 weeks old, 250350 g) were purchased from the Multidisciplinary Center for Biological Investigation (CEMIB), University of Campinas (UNICAMP), Campinas, SP, Brazil, and housed at the Multidisciplinary Animal Experimentation Unit (UMEA), Faculty of Medical Sciences (FCM), UNICAMP, in groups of three animals per cage with free access to standard feed and water

doi: 10.1007/s12298-025-01662-7 18 BonneauL.HuguetS.WipfD.PaulyN.TruongH

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The mean 4-week migraine headache rate during the treatment phase was 5.7 in the placebo group compared to 3.5 in the Depakote group (see Figure 4)

Moreover, in the presence of muramyl dipeptide, Vitamin D synergistically induces NF-B activity as well as the expression of DEFB2/HBD2 and cathelicidin, thereby constraining the overgrowth of opportunistic pathogens [239]

The condition is characterized by altered lipid metabolism in the liver and adipose tissue, contributing to elevated levels of inflammatory markers such as IL-6, TNF-, and CRP (Taylor et al., 2021)