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The cohort from HSAC refers to consecutive patients followed for chronic HBV infection between January 2018 and December 2019

The means of different groups were compared using the Student (t) test

p=0.036)

Guanine's N7 position is exposed in the major groove of double-helical DNA, making it more suitable for adduction than when compared to adenine's N3 position, which is orientated in the minor groove

No dose adjustments should be required for triazolam or other sedative hypnotics in patients cotreated with dexamethasone, given that its moderate inducer activity on CYP3A4 occurs at high doses (above 1624 mg/day) [86]

Metabolic changes during degeneration increase ROS production and impair mitochondrial function, causing mitochondrial fragmentation and apoptosis in NPCs (Figure 2)