While the energetic effects fade after 2 to 4 weeks, vitamin B12 itself continues to be stored in the liver and can remain available for years

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Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives
The time when you will notice significant changes in response to B12 supplementation is when you ask how long B12 takes to work
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Vitamin B12 helps your body produce new, healthy cells and protect your nerves