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In recent years, intranasal (IN) drug delivery has emerged as a promising strategy to bypass the BBB, providing a direct nose-to-brain delivery route via olfactory and trigeminal pathways while minimizing systemic exposure

doi: 10.1016/j.mito.2024.101858 72

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That said, the researchers didnt find a significant effect in the short term, and they concluded that more research is needed

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AOD-9604: The AOD-9604 peptide remains unapproved in most markets despite extensive research