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Several important limitations of this study should be considered when interpreting the findings

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Statistical differences were calculated by 2-way ANOVA with Sidaks correction for multiple comparisons, or by unpaired two-tailed t-tests

Results: 215 patients achieving HBsAg seroclearance were enrolled in the present study including 164 and 51 patients in the none-NUC consolidation group and NUC consolidation group, respectively