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Additionally, p40 phox has been implicated in the resolution of intestinal inflammation in a DSS-colitis model by regulating Ccr1 expression in PMNs and expression of enzymes responsible for glycan modifications (Conway et al., Small G proteins Small G proteins, especially those belonging to the Rho family of small guanine triphosphatase (GTPases), play an important role in the regulation of NADPH oxidase (Miyano and Sumimoto, 2012)