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Furthermore, formulation-dependent variations complicate clinical use, as enhanced-bioavailability products, though more effective systemically, may also increase the risk of toxicity and drug interactions

Mechanistically, PSAT1 activates STAT3 signaling pathway through its interactiopm with IQGAP1, and this effect remains even in the presence of catalytically inactive PSAT1 mutants [126] (Fig

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Genetic and proteomic studies point to what is happening at the tissue level Aldo-keto reductase 1C1: One of the first genes identified as likely being involved in lipedema is AKR1C1, which encodes aldo-keto reductase family 1 member C1