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(See Holford et al, 2013, for parameters in neonates and children.) Knowing the relationship between dose, drug concentration, and effects allows the clinician to take into account the various pathologic and physiologic features of a particular patient that make him or her different from the average individual in responding to a drug

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Therefore, those with a low tolerance to alcohol will notice effects at lower BACs, while those with a higher tolerance will notice them somewhat later