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Aerts, L., Craessaerts, K., De Strooper, B

Metabolites that were not significantly different between groups were excluded from further statistical analysis

Larger doses up to 600800 milligrams per day are sometimes used in patients with diabetes or cognitive disorders but not recommended for the general public

Despite being pharmacologically inert on their own, these compounds exhibited a significant impact on the activity of the target compound, giving rise to the concept known as the entourage effect. This effect refers to modifying the pharmacological properties of individual molecules through interactions with co-existing metabolites, even if these metabolites lack inherent pharmacological activity [147]