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Using bisulfite-based NGS analysis, the authors revealed that increased DNA methylation of carbonic anhydrase 10 ( CA10 ), dipeptidyl peptidase like 10 ( DPP10 ), formin 2 ( FMN2 ), and hyaluronan synthase 1 ( HAS1 ), both individually and in combination, accurately discriminated precancerous lesions (CIN1, CIN2, and CIN3) and CC patients from healthy controls (SE: 84.3%

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10.1164/ajrccm.163.7.2011060 3