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The balance between genotoxins and benign metabolites is presumed to depend on concentration, localization, pH and redox state, features that are or potentially altered during disease progression (Hopkinson and Schofield, 2018)

According to the National Library of Medicine, an e-cig will typically enable about 500 puffs, which is equivalent to roughly 50 conventional cigarettes, making them more compact and inventory easier to manage (compared to traditional cigarettes)

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However, this depends on the e-cigarette product, which have varying amounts of nicotine

Increasing social acceptability of alcohol and smoking, and increasing socialization also has some role