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Description

The rationale for senolytics is that clearing these cells removes their chronic SASP burden, allowing tissue homeostasis to be partially restored

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[2] Kim J, Jung Y

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In the published literature the combination is investigated for body-weight reduction and glycemic control , on the hypothesis that engaging the amylin and GLP-1 pathways together influences appetite and energy balance more than either agent does alone [3]

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This observation raises questions about the underlying mechanisms of senescence and the necessity of addressing the root causes that drive cellular senescence, rather than merely focusing on the symptomatic removal of senescent cells

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